Glycolytic competence in gastric adenocarcinomas negatively impacts survival outcomes of patients treated with salvage paclitaxel-ramucirumab.

doi:10.1007/s10120-020-01078-0

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Article

Glycolytic competence in gastric adenocarcinomas negatively impacts survival outcomes of patients treated with salvage paclitaxel-ramucirumab.

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association - 1 Nov 2020

Ruzzo Annamaria, Graziano Francesco, Bagaloni Irene, Di Bartolomeo Maria, Prisciandaro Michele, Aprile Giuseppe, Ongaro Elena, Vincenzi Bruno, Perrone Giuseppe, Santini Daniele, Fornaro Lorenzo, Vivaldi Caterina, Tomasello Gianluca, Loupakis Fotios, Lonardi Sara, Fassan Matteo, Valmasoni Michele, Sarti Donatella, Lorenzini Paola, Catalano Vincenzo, Bisonni Renato, Del Prete Michela, Collina Guido, Magnani Mauro

Abstract excerpt

INTRODUCTION: For energy production, cancer cells maintain a high rate of glycolysis instead of oxidative phosphorylation converting glucose into lactic acid. This metabolic shift is useful to survive in unfavorable microenvironments. We investigated whether a positive glycolytic profile (PGP) in gastric adenocarcinomas may be associated with unfavorable outcomes under an anticancer systemic therapy, including...

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PMID: 32372141
DOI: 10.1007/s10120-020-01078-0
PMCID: PMC7567716

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