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Article

Structure of a mutated photosystem II complex reveals changes to the hydrogen-bonding network that affect proton egress during O-O bond formation.

The Journal of biological chemistry - 1 Mar 2025

Flesher David A, Shin Jieun, Debus Richard J, Brudvig Gary W

Abstract excerpt

Photosystem II (PSII) is the water-splitting enzyme of oxygenic photosynthesis. Using light energy, PSII catalytically oxidizes two water molecules to fuel downstream metabolism, forming an O-O bond and releasing O2 as a byproduct. The reaction mechanism requires the strategic removal of four protons via conserved hydrogen-bonding networks, but these pathways remain poorly understood. Site-directed mutagenesis...

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Identifiers

PMID: 39922494
DOI: 10.1016/j.jbc.2025.108272
PMCID: PMC11930075

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