Autism common variants associated with white matter alterations at birth: cross-sectional fixel-based analyses of 221 European term-born neonates from the developing human connectome project.

doi:10.1038/s41398-025-03252-3

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Autism common variants associated with white matter alterations at birth: cross-sectional fixel-based analyses of 221 European term-born neonates from the developing human connectome project.

Translational psychiatry - 4 Feb 2025

Le Hai, Bonthrone Alexandra F, Uus Alena, Fenchel Daphna, Lautarescu Alexandra, Dimitrakopoulou Konstantina, Edwards A David, Hajnal Joseph V, Counsell Serena J, Cordero-Grande Lucilio, Christiaens Daan, Batalle Dafnis, Pietsch Maximilian, Price Anthony N, Patel Hamel, Curtis Charles, Cullen Harriet, Deprez Maria, Tournier Jacques-Donald

Abstract excerpt

Increasing lines of evidence suggest white matter (WM) structural changes associated with autism can be detected in the first year of life. Despite the condition having high heritability, the relationship between autism common genetic variants and WM changes during this period remains unclear. By employing advanced regional and whole-brain fixel-based analysis, the current study investigated the association...

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Topics

Humans
White Matter
Connectome
Female

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Male

Cross-Sectional Studies

Autistic Disorder

Polymorphism, Single Nucleotide

Infant, Newborn

Magnetic Resonance Imaging

Brain

Multifactorial Inheritance

White People

Source

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Identifiers

PMID: 39905010
DOI: 10.1038/s41398-025-03252-3
PMCID: PMC11794609

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