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Article

Distinct Neonatal Brain Anatomy Is Associated With Cross-Disorder Genetic Risk for Psychiatric Disorders.

Human brain mapping - 15 Apr 2026

Dang Xixi, Su Ruiqi, Wu Dan, Li Mingyang

Abstract excerpt

Psychiatric disorders share a complex polygenic architecture, yet how this genetic liability relates to early brain development remains unclear. This study investigated the associations between cross-disorder polygenic risk and neonatal brain anatomy. We derived three latent psychiatric factors using GenomicSEM, reflecting shared genetic liability among related conditions: A neurodevelopmental factor, a...

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Identifiers

PMID: 42003227
DOI: 10.1002/hbm.70532
PMCID: PMC13092910

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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