An extreme mutational hotspot in nlpD depends on transcriptional induction of rpoS.

Abstract excerpt

Mutation rate varies within and between genomes. Within genomes, tracts of nucleotides, including short sequence repeats and palindromes, can cause localised elevation of mutation rate. Additional mechanisms remain poorly understood. Here we report an instance of extreme mutational bias in Pseudomonas fluorescens SBW25 associated with a single base-pair change in nlpD. These mutants frequently evolve in static...

Topics

• Sigma Factor
• Bacterial Proteins
• Promoter Regions, Genetic
• Gene Expression Regulation, Bacterial
• Pseudomonas fluorescens
• Mutation