Article
Spiking Patterns in the Globus Pallidus Highlight Convergent Neural Dynamics across Diverse Genetic Dystonia Syndromes.
Annals of neurology - 1 May 2025
Kaymak Ahmet, Colucci Fabiana, Ahmadipour Mahboubeh, Andreasi Nico Golfrè, Rinaldo Sara, Israel Zvi, Arkadir David, Telese Roberta, Levi Vincenzo, Zorzi Giovanna, Carpaneto Jacopo, Carecchio Miryam, Prokisch Holger, Zech Michael, Garavaglia Barbara, Bergman Hagai, Eleopra Roberto, Mazzoni Alberto, Romito Luigi M
Abstract excerpt
OBJECTIVE: Genetic dystonia is a complex movement disorder with diverse clinical manifestations resulting from pathogenic mutations in associated genes. A recent paradigm shift emphasizes the functional convergence among dystonia genes, hinting at a shared pathomechanism. However, the neural dynamics supporting this convergence remain largely unexplored. METHODS: Herein, we analyzed microelectrode recordings...
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