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Sympathetic innervation induced by nerve growth factor promotes malignant transformation in gastric cancer

30 Jan 2025

Abstract excerpt

Sympathetic nerves regulate nearly all human organs. Their peripheral nerves are present in tumor tissue. Activation of the sympathetic nervous system promotes malignant transformation in several cancers. This study aimed to quantify sympathetic nerve density (SND) in gastric cancer and investigate the relationship between SND and nerve growth factor (NGF) in human clinical samples using immunohistochemistry....

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PMID: 39885251
DOI: 10.1038/s41598-025-87492-9

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