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Article

Impaired Resting-State Functional Connectivity in Cerebral Autosomal-Dominant Arteriopathy, Subcortical Infarcts, and Leukoencephalopathy Mutant Mice.

Stroke - 1 Apr 2025

Aykan Sanem Aslihan, Lai James Han, Sugimoto Kazutaka, Aykan Orhan, Fung Wai Yee, Ho David, Joutel Anne, Sakadzic Sava, Chung David Y, Ayata Cenk

Abstract excerpt

BACKGROUND: Cerebral autosomal-dominant arteriopathy, subcortical infarcts, and leukoencephalopathy is the most prevalent monogenic inherited cause of cerebral small vessel disease. Despite its prevalence, there is currently no proven therapy to prevent or reverse the progression of the disease. METHODS: This study aimed to characterize the functional integrity of long white matter tracts in cerebral...

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PMID: 39882613
DOI: 10.1161/STROKEAHA.124.049772
PMCID: PMC11932795

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