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Spatially resolved transcriptomics and graph-based deep learning improve accuracy of routine CNS tumor diagnostics

29 Jan 2025

Abstract excerpt

The diagnostic landscape of brain tumors integrates comprehensive molecular markers alongside traditional histopathological evaluation. DNA methylation and next-generation sequencing (NGS) have become a cornerstone in central nervous system (CNS) tumor classification. A limiting requirement for NGS and methylation profiling is sufficient DNA quality and quantity, which restrict its feasibility. Here we...

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PMID: 39880907
DOI: 10.1038/s43018-024-00904-z

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