Causal relationships between immune cells, inflammatory factors, and preeclampsia: A two-step, two-sample mendelian randomization study.

Abstract excerpt

BACKGROUND: Preeclampsia (PE) is a complex hypertensive disorder that occurs during pregnancy, with the immune system playing a key role. Although immune modulation is implicated in PE progression, the roles of specific immune cells and inflammatory mediators remain unclear. METHODS: We conducted a two-sample, two-step Mendelian randomization (MR) analysis, primarily using the inverse-variance weighted method, to...

Topics

• Humans
• Pre-Eclampsia
• Female
• Pregnancy
• Mendelian Randomization Analysis
• HLA-DR Antigens