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TDP43 augments astrocyte inflammatory activity through mtDNA-cGAS-STING axis in NMOSD

22 Jan 2025

Abstract excerpt

Abnormality in transactivating response region DNA binding protein 43 (TDP43) is well-recognized as the pathological hallmark of neurodegenerative diseases. However, the role of TDP43 in neuromyelitis optica spectrum disorder (NMOSD) remains unknown. Here, our observations demonstrate an upregulation of TDP43 in both in vitro and in vivo models of NMOSD, as well as in biological samples from NMOSD patients....

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PMID: 39844196
DOI: 10.1186/s12974-025-03348-z

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