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Clinical Validation of Optical Genome Mapping in Multiple Myeloma Without Plasma Cell Enrichment

17 Jan 2025

Abstract excerpt

Cytogenetic alterations are important in risk stratification for multiple myeloma (MM). Translocations involving the immunoglobulin heavy chain (IGH), such as t(4;14), t(14;16), as well as del(17p) and gain(1q), are recognized as high-risk cytogenetic markers in staging systems [1]. Fluorescence in situ hybridization (FISH) is the primary method for detecting these genetic alterations. However, cytogenetic...

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PMID: 39821944
DOI: 10.1002/ajh.27589

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