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Article

Uromodulin and Risk of Upper Urinary Tract Infections: A Mendelian Randomization Study.

American journal of kidney diseases : the official journal of the National Kidney Foundation - 1 May 2025

Liyanarachi Kristin Vardheim, Flatby Helene, Hallan Stein, Åsvold Bjørn Olav, Damås Jan Kristian, Rogne Tormod

Abstract excerpt

RATIONALE & OBJECTIVE: Observational studies suggest that uromodulin, produced by the kidneys, is associated with a reduced risk of upper urinary tract infections (UTIs), but inferences are limited by potential confounding factors. This study sought to explore further the validity of this association using Mendelian randomization (MR). STUDY DESIGN: Two-sample MR study. SETTING & PARTICIPANTS: The study included...

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Genome-Wide Association Study
Kidney Stones and Urolithiasis Treatments
Mendelian Randomization Analysis
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Urinary Tract Infections

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PMID: 39805364
DOI: 10.1053/j.ajkd.2024.11.007

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