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The KMeansGraphMIL Model: A Weakly Supervised Multiple Instance Learning Model for Predicting Colorectal Cancer Tumor Mutational Burden.

The American journal of pathology - 1 Apr 2025

Chen Linghao, Xiao Huiling, Jiang Jiale, Li Bing, Liu Weixiang, Huang Wensheng

Abstract excerpt

Colorectal cancer (CRC) is one of the top three most lethal malignancies worldwide, posing a significant threat to human health. Recently proposed immunotherapy checkpoint blockade treatments have proven effective for CRC, but their use depends on measuring specific biomarkers in patients. Among these biomarkers, tumor mutational burden (TMB) has emerged as a novel indicator, traditionally requiring...

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PMID: 39800053
DOI: 10.1016/j.ajpath.2024.12.008

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