Article
Host cell lectins ASGR1 and DC-SIGN jointly with TMEM106B confer ACE2 independence and imdevimab resistance to SARS-CoV-2 pseudovirus with spike mutation E484D.
Journal of virology - 25 Feb 2025
Arora Prerna, Zhang Lu, Nehlmeier Inga, Kempf Amy, Graichen Luise, Kreitz Eike, Sidarovich Anzhalika, Rocha Cheila, Gärtner Sabine, Winkler Michael, Schulz Sebastian, Jäck Hans-Martin, Hoffmann Markus, Pöhlmann Stefan
Abstract excerpt
The naturally occurring mutation E484D in the spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can render viral entry ACE2 independent and imdevimab resistant. Here, we investigated whether the cellular proteins ASGR1, DC-SIGN, and TMEM106B, which interact with the viral S protein, can contribute to these processes. Employing S protein-pseudotyped particles, we found that...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.