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Article

Impact of population screening for Lynch syndrome insights from the All of Us data.

Nature communications - 9 Jan 2025

Park Jiheum, Karnati Hemanth, Rustgi Sheila D, Hur Chin, Kong Xiao-Fei, Kastrinos Fay

Abstract excerpt

Lynch Syndrome (LS) is a common genetic cancer condition that allows for personalized cancer prevention and early cancer detection in identified gene carriers. We used data from the All of Us (AOU) Research Initiative to assess the prevalence of LS in the general U.S. population, and analyzed demographic, personal, and family cancer history, stratified by LS genotype to compare LS and non-LS carriers. The results...

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Topics

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Share to Colorectal Neoplasms, Hereditary Nonpolyposis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Testing

Share to Germ-Line Mutation

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Share to Mismatch Repair Endonuclease PMS2

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Source

Open in PubMed Open full text

Identifiers

PMID: 39788943
DOI: 10.1038/s41467-024-52562-5
PMCID: PMC11718231

Genes

MSH6
PMS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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