Article
Functional landscapes of POLE and POLD1 mutations in checkpoint blockade-dependent antitumor immunity.
Nature genetics - 1 Jul 2022
Ma Xiaoxiao, Riaz Nadeem, Samstein Robert M, Lee Mark, Makarov Vladimir, Valero Cristina, Chowell Diego, Kuo Fengshen, Hoen Douglas, Fitzgerald Conall W R, Jiang Hui, Alektiar Jonathan, Alban Tyler J, Juric Ivan, Parthasarathy Prerana Bangalore, Zhao Yu, Sabio Erich Y, Verma Richa, Srivastava Raghvendra M, Vuong Lynda, Yang Wei, Zhang Xiao, Wang Jingming, Chu Lawrence K, Wang Stephen L, Kelly Daniel W, Pei Xin, Chen Jiapeng, Yaeger Rona, Zamarin Dmitriy, Zehir Ahmet, Gönen Mithat, Morris Luc G T, Chan Timothy A
Abstract excerpt
Defects in pathways governing genomic fidelity have been linked to improved response to immune checkpoint blockade therapy (ICB). Pathogenic POLE/POLD1 mutations can cause hypermutation, yet how diverse mutations in POLE/POLD1 influence antitumor immunity following ICB is unclear. Here, we comprehensively determined the effect of POLE/POLD1 mutations in ICB and elucidated the mechanistic impact of these mutations...
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