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Article

Plasmodium falciparum surf4.1 in clinical isolates: From genetic variation and variant diversity to in silico design immunopeptides for vaccine development.

PloS one - 1 Jan 2024

Noranate Nitchakarn, Sripanomphong Jariya, Mphande-Nyasulu Fingani Annie, Chaorattanakawee Suwanna

Abstract excerpt

SURFINs protein family expressed on surface of both infected red blood cell and merozoite surface making them as interesting vaccine candidate for erythrocytic stage of malaria infection. In this study, we analyze genetic variation of Pfsurf4.1 gene, copy number variation, and frequency of SURFIN4.1 variants of P. falciparum in clinical isolates. In addition, secondary structure prediction and immunoinformatic...

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Identifiers

PMID: 39775228
DOI: 10.1371/journal.pone.0312091
PMCID: PMC11684625

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