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Article

Engineering Protein Dynamics through Mutational Energy Landscape Traps.

Journal of chemical information and modeling - 27 Jan 2025

Machado Lucas de Almeida, Sartori João, Franklin Paula Fernandes da Costa, Costa Mauricio G S, Guimarães Ana Carolina Ramos

Abstract excerpt

Protein dynamics is essential for various biological processes, influencing functions such as enzyme activity, molecular recognition, and signal transduction. However, traditional protein engineering methods often focus on static structures, lacking tools to precisely manipulate dynamic behaviors. Here, we developed Mutational Energy Landscape Trap (MELT), a novel method designed to control protein dynamics by...

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PMID: 39772594
DOI: 10.1021/acs.jcim.4c01928
PMCID: PMC11776041

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