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Genetic variations of MTHFR gene and their association with preterm birth in Korean women.

Medicina (Kaunas, Lithuania) - 1 Jan 2017

Hwang In Wook, Kang Yun Dan, Kwon Bit Na, Hong Jun Ho, Han Seung Hun, Kim Jong Soo, Park Jin Wan, Jin Han Jun

Abstract excerpt

BACKGROUND AND OBJECTIVE: The MTHFR gene encodes the methylenetetrahydrofolate reductase known to be involved in the homocysteine-methionine pathway. It has been reported that the deficiency of MTHFR activity may cause hyperhomocysteinemia which results in adverse pregnancy outcomes. Previous studies reported a correlation between the MTHFR gene polymorphisms (677 T/C and 1298 A/C) and lower MTHFR activity and...

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Identifiers

PMID: 29428336
DOI: 10.1016/j.medici.2018.01.001

Genes

MTHFR

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