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Natural Mutation of PrfA K10N/T151A Enhances Serotype 4h Listeria monocytogenes Virulence.

Foodborne pathogens and disease - 1 Nov 2025

Li Jing, Cai Xuexue, Wang Luyong, Wang Ruochen, Meng Fanzeng, Wang Ye, Jiao Xin'an, Yin Yuelan, Wang Zegang

Abstract excerpt

PrfA is a key virulence regulator for Listeria monocytogenes (Lm) responding to host environment. Here we report that the natural mutation in PrfAK10N/T151A enhanced the pathogenicity of hypervirulent serotype 4h L. monocytogenes. We characterized the phylogenetic tree of PrfA, and found that PrfAK10N/T151A prevalently distributed in all serotype 4h isolates. Remarkably, the growth rate of serotype 4h strain Lm...

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PMID: 39761127
DOI: 10.1089/fpd.2024.0050

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