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Deciphering m6A signatures in hepatocellular carcinoma: Single‐cell insights, immune landscape, and the protective role of IGFBP3

16 Feb 2024

Abstract excerpt

RNA m6 methyladenosine (m6A) modifications impact tumor biology and immune processes, particularly in hepatocellular malignant tumors. Using a consensus clustering algorithm on 371 hepatocellular carcinoma (HCC) samples, we identified three m6A-modified subtypes and correlated them with positive tumor microenvironment (TME) markers for distinct immune phenotypes. Stratifying patients based on m6A scores revealed...

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PMID: 38366283
DOI: 10.1002/tox.24177

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