Article
S100A proteins show a spatial distribution of inflammation associated with the glioblastoma microenvironment architecture.
Theranostics - 1 Jan 2025
Cómitre-Mariano Blanca, Segura-Collar Berta, Vellila-Alonso Gabriel, Contreras Rubén, Henandez-Lain Aurelio, Valiente Manuel, Sepulveda Juan M, Marcus Stephen Garrett, García-Posadas Guillermo, Jiménez-Roldán Luis, Perez-Nuñez Ángel, Gargini Ricardo
Abstract excerpt
Background: Glioblastoma IDH wild type (GBM IDH wt) has a poor prognosis and a strongly associated with inflammatory processes. Inflammatory molecules generate positive feedback with tumor cells fueling tumor growth as well as recruitment of immune cells that promote aggressiveness. Although the role of many inflammatory molecules is well known, there are many macromolecules, such as the S100A proteins, whose...
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