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Article

Evaluating the impact of modeling choices on the performance of integrated genetic and clinical models.

Genetics in medicine : official journal of the American College of Medical Genetics - 1 Apr 2025

Morley Theodore J, Willimitis Drew, Ripperger Michael, Lee Hyunjoon, Zhou Yu, Han Lide, Kang Jooeun, Meyerson William U, Smoller Jordan W, Choi Karmel W, Walsh Colin G, Ruderfer Douglas M

Abstract excerpt

PURPOSE: The value of genetic information for improving the performance of clinical risk prediction models has yielded variable conclusions. Many methodological decisions have the potential to contribute to differential results. We performed multiple modeling experiments integrating clinical and demographic data from electronic health records with genetic data to understand which decisions may affect performance....

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Source

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Identifiers

PMID: 39733260
DOI: 10.1016/j.gim.2024.101353
PMCID: PMC13183356

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