Impact of SCN10A Polymorphism on Abdominal Pain Perception and Visceral Hypoalgesia in Crohn's Disease and Ulcerative Colitis.

doi:10.14309/ctg.0000000000000778

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Impact of SCN10A Polymorphism on Abdominal Pain Perception and Visceral Hypoalgesia in Crohn's Disease and Ulcerative Colitis.

Clinical and translational gastroenterology - 1 Dec 2024

Coates Matthew D, Walter Vonn, Stuart August, Small Jeffrey, Dalessio Shannon, Carkaci-Salli Nurgul, Ouyang Ann, Clarke Kofi, Tinsley Andrew, Williams Emmanuelle D, Janicki Piotr, Ruiz-Velasco Victor, Vrana Kent E

Abstract excerpt

INTRODUCTION: Hypoalgesic inflammatory bowel disease (IBD) may provide critical insights into human abdominal pain. This condition was previously associated with homozygosity for a polymorphism (rs6795970, A1073V; 1073 val/val ) related to Na v 1.8, a voltage-gated sodium channel preferentially expressed on nociceptors. It was unclear whether this relationship existed for both Crohn's disease (CD) and ulcerative...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Abdominal Pain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Case-Control Studies

Share to Colitis, Ulcerative

Share to Crohn Disease

Share to Gene Frequency

Share to Homozygote

Share to Polymorphism, Single Nucleotide

Share to Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 39729348
DOI: 10.14309/ctg.0000000000000778
PMCID: PMC11671066

Genes

SCN10A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impact of SCN10A Polymorphism on Abdominal Pain Perception and Visceral Hypoalgesia in Crohn's Disease and Ulcerative Colitis.PMID 39729348Read ↗

Homozygosity for the SCN10A Polymorphism rs6795970 Is Associated With Hypoalgesic Inflammatory Bowel Disease PhenotypeSemantic proximity Read ↗

Gene polymorphisms associated with functional dyspepsia.Semantic proximity Read ↗

Genetics of human gastrointestinal sensation.Semantic proximity Read ↗

Identification of Arginine-Vasopressin Receptor 1a (Avpr1a/Avpr1a) as a Novel Candidate Gene for Chronic Visceral Pain Sheds Light on the Potential Role of Enteric Neurons in the Development of Visceral Hypersensitivity.Semantic proximity Read ↗

Identification of arginine-vasopressin receptor 1a (Avpr1a/AVPR1A) as a novel candidate gene for chronic visceral painSemantic proximity Read ↗

Abdominal pain in patients with inflammatory bowel disease: association with single-nucleotide polymorphisms prevalent in irritable bowel syndrome and clinical management.Semantic proximity Read ↗

Transcriptomic profiling reveals a pro-nociceptive role for Angiotensin II in inflammatory bowel diseaseSemantic proximity Read ↗

IBS and IBD - separate entities or on a spectrum?Semantic proximity Read ↗

Association of distinct alpha(2) adrenoceptor and serotonin transporter polymorphisms with constipation and somatic symptoms in functional gastrointestinal disorders.Semantic proximity Read ↗

Genetic variation in endocannabinoid metabolism, gastrointestinal motility, and sensation.Semantic proximity Read ↗

Neuropeptide s receptor 1 gene polymorphism is associated with susceptibility to inflammatory bowel disease.Semantic proximity Read ↗

Functional dyspepsia susceptibility is related to CD14, GNB3, MIF, and TRPV1 gene polymorphisms in the Greek population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.