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Article

EGFR, TP53, and CUL3 Triple Mutation in Non-Small Cell Lung Cancer and its Potentially Poor Prognosis: A Case Report and Database Analysis.

Thoracic cancer - 1 Feb 2025

Hatano Hiroto, Yoshida Tatsuya, Higashiyama Ryoko, Torasawa Masahiro, Uehara Yuji, Ohe Yuichiro

Abstract excerpt

Concurrent mutations in tumor protein p53 (TP53) or Kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2-pathway components are linked to poor outcomes in epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC), but the impact of triple mutations remains unclear. We report a case of EGFR-, TP53-, and Cullin 3 (CUL3)-mutant NSCLC in a 43-year-old woman with...

Read the complete abstract on PubMed

Topics

ErbB Receptors
Tumor Suppressor Protein p53
Mutation
Carcinoma, Non-Small-Cell Lung
Lung Neoplasms
Prognosis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Humans

Female

Adult

Fatal Outcome

Databases as Topic

Cullin Proteins

Mutation Rate

Kaplan-Meier Estimate

Source

Open in PubMed Open full text

Identifiers

PMID: 39727229
DOI: 10.1111/1759-7714.15523
PMCID: PMC11788012

Genes

EGFR
TP53
CUL3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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