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Ring finger protein 5 mediates STING degradation through ubiquitinating K135 and K155 in a teleost fish

11 Dec 2024

Abstract excerpt

Stimulator of interferon genes (STING) is a key connector protein in interferon (IFN) signaling, crucial for IFN induction during the activation of antiviral innate immunity. In mammals, ring finger protein 5 (RNF5) functions as an E3 ubiquitin ligase, mediating STING regulation through K150 ubiquitylation to prevent excessive IFN production. However, the mechanisms underlying RNF5’s regulation of STING in...

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PMID: 39723209
DOI: 10.3389/fimmu.2024.1525376

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