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Article

The correlation between primary ovarian insufficiency, sex hormones and immune cells: a two-step Mendelian randomization study

14 Feb 2025

Abstract excerpt

Background: Primary ovarian insufficiency (POI), a cause of female infertility, is characterized by elevated gonadotropin levels and fluctuating estrogen reductions, accompanied by irregular menstruation, osteoporosis, cardiovascular disease, and genitourinary syndrome of menopause. Previous studies have shown an association between POI and immune cells, but the causal relationship remains unclear. Sex hormones...

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PMID: 40026688
DOI: 10.3389/fendo.2025.1456273

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