Article
Exploring Compactness and Dynamics of Apomyoglobin.
Proteins - 1 May 2025
Glyakina Anna V, Suvorina Mariya Y, Dovidchenko Nikita V, Katina Natalya S, Surin Alexey K, Galzitskaya Oxana V
Abstract excerpt
Hydrogen-deuterium exchange mass spectrometry (HDX-MS) approach has become a valuable analytical complement to traditional methods. HDX-MS allows the identification of dynamic surfaces in proteins. We have shown that the introduction of various mutations into the amino acid sequence of whale apomyoglobin (apoMb) leads to a change in the number of exchangeable hydrogen atoms, which is associated with a change in...
Topics
- Myoglobin
- Apoproteins
- Animals
- Amino Acid Substitution
- Hydrogen Deuterium Exchange-Mass Spectrometry
- Amino Acid Sequence
- Mutation
- Sperm Whale
- Protein Conformation
- Models, Molecular
- Whales
- Molecular Dynamics Simulation