Article
Early detection of colorectal cancer using aberrant circulating cell-free mitochondrial DNA fragmentomics
18 Dec 2024
Abstract excerpt
BACKGROUND: Early detection of colorectal cancer (CRC) is crucial for improving the survival rates of patients. OBJECTIVE: We aimed to develop a novel strategy for early CRC detection using the fragmentomic features of circulating cell-free mitochondrial DNA (ccf-mtDNA). DESIGN: Here, a total of 1147 participants, including 478 healthy controls (HCs), 112 patients with advanced adenomas (AAs) and 557 patients...