Article
PITX2 expression and Neanderthal introgression in HS3ST3A1 contribute to variation in tooth dimensions in modern humans.
Current biology : CB - 6 Jan 2025
Li Qing, Faux Pierre, Wentworth Winchester Emma, Yang Guangrui, Chen Yingjie, Ramírez Luis Miguel, Fuentes-Guajardo Macarena, Poloni Lauriane, Steimetz Emilie, Gonzalez-José Rolando, Acuña Victor, Bortolini Maria-Cátira, Poletti Giovanni, Gallo Carla, Rothhammer Francisco, Rojas Winston, Zheng Youyi, Cox James C, Patel Vaishali, Hoffman Matthew P, Ding Li, Peng Chenchen, Cotney Justin, Navarro Nicolas, Cox Timothy C, Delgado Miguel, Adhikari Kaustubh, Ruiz-Linares Andrés
Abstract excerpt
Dental morphology varies greatly throughout evolution, including in the human lineage, but little is known about the biology of this variation. Here, we use multiomics analyses to examine the genetics of variation in tooth crown dimensions. In a human cohort with mixed continental ancestry, we detected genome-wide significant associations at 18 genome regions. One region includes EDAR, a gene known to impact...
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