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Article

TransferGWAS of T1-weighted brain MRI data from UK Biobank.

PLoS genetics - 1 Dec 2024

Rakowski Alexander, Monti Remo, Lippert Christoph

Abstract excerpt

Genome-wide association studies (GWAS) traditionally analyze single traits, e.g., disease diagnoses or biomarkers. Nowadays, large-scale cohorts such as UK Biobank (UKB) collect imaging data with sample sizes large enough to perform genetic association testing. Typical approaches to GWAS on high-dimensional modalities extract predefined features from the data, e.g., volumes of regions of interest. This limits the...

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PMID: 39671448
DOI: 10.1371/journal.pgen.1011332
PMCID: PMC11687923

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