Article

Elucidating the Biological Effects of Cell-Free DNA (cfDNA) Extracted from Septic Mice: In Vitro and In Vivo Investigations and Mechanistic Insights

2023-12-27

Abstract excerpt

cfDNA is known to be a beneficial biomarker for the diagnosis, treatment response, and prognosis of sepsis. Previous cell line studies have shown that cfDNA in septic mice triggers inflammatory responses and tissue damage, and the mechanism occurs by binding to toll-like receptors (TLRs). Meanwhile, reactive oxidative species (ROS) and nitric oxide (NO) are increased in sepsis, which is known to be associated with...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ea6e1123-a46a-529c-9947-78ce0d0637e9
DOI: 10.20944/preprints202312.2066.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Elucidating the Biological Effects of Cell-Free DNA (cfDNA) Extracted from Septic Mice: In Vitro and In Vivo Investigations and Mechanistic InsightsDOI 10.20944/preprints202312.2066.v1Read

Cell-Free DNA as Biomarker for Sepsis by Integration of Microbial and Host InformationSemantic proximity Read

Cell-Free Nuclear and Mitochondrial DNA as Potential Biomarkers for Assessing Sepsis SeveritySemantic proximity Read

Mitochondrial DNASemantic proximity Read

Prognostic utility and characterization of cell-free DNA in patients with severe sepsisSemantic proximity Read

Red blood cells capture and deliver bacterial DNA to drive host responses during polymicrobial sepsisSemantic proximity Read

MPO-DNA Complexes and cf-DNA in Patients with Sepsis and Their Clinical ValueSemantic proximity Read

Clinical Significance of MDSCs in Patients with SepsisSemantic proximity Read

Noncoding RNAs in sepsis-associated acute liver injury: Roles, mechanisms, and therapeutic applicationsSemantic proximity Read

Unraveling NETs in Sepsis: From Cellular Mechanisms to Clinical RelevanceSemantic proximity Read

Oxidized Cell-Free DNA Is a Factor of Stress Signaling in Radiation-Induced Bystander Effects in Different Types of Human CellsSemantic proximity Read

Cell-Free DNA in the Pathogenesis and Therapy of Non-Infectious Inflammations and TumorsSemantic proximity Read

CpG DNA: Trigger of Sepsis, Mediator of Protection, or Both?Semantic proximity Read