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Controlled aggregative assembly to form self-organizing macroscopic human intestine from induced pluripotent stem cells

1 Dec 2024

Abstract excerpt

Human intestinal organoids (HIOs) derived from human pluripotent stem cells (hPSCs) are promising resources for intestinal regenerative therapy as they recapitulate both endodermal and mesodermal components of the intestine. However, due to their hPSC-line-dependent mesenchymal development and spherical morphology, HIOs have limited applicability beyond basic research and development. Here, we demonstrate the...

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PMID: 39662475
DOI: 10.1016/j.crmeth.2024.100930

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