The frequency of known germline LGR4 missense variant in the ethnic groups of West Siberia.

doi:10.1007/s11033-024-10133-3

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The frequency of known germline LGR4 missense variant in the ethnic groups of West Siberia.

Molecular biology reports - 7 Dec 2024

Gervas Polina, Molokov Aleksey, Babyshkina Nataliya, Zherebnova Anna, Choynzonov Evgeny, Cherdyntseva Nadezda

Abstract excerpt

BACKGROUND: Hereditary breast cancer is an autosomal dominant disease caused by variants in genes such as BRCA1/2, RAD51, ATM, BRIP1, and others. In a previous study using whole exome sequencing, we identified a germline variant of the LGR4 gene (rs34804482, NM_018490.5(LGR4):c.2531 A > G (p.Asp844Gly)) in a young Tuvan breast cancer patient (belonging to the Turkic-speaking tribes of Central Asia). The aim of...

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PMID: 39644398
DOI: 10.1007/s11033-024-10133-3

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