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Article

Unraveling the mechanisms underlying diabetic cataracts: insights from Mendelian randomization analysis.

Redox report : communications in free radical research - 1 Dec 2024

Liu Wenlan, Pan Yiming

Abstract excerpt

BACKGROUND: Diabetic cataract (DC) is a major cause of blindness, with its pathogenesis involving oxidative stress and ferroptosis, according to recent studies. METHODS: We performed a Mendelian Randomization (MR) study using GWAS data to select SNPs and assess the causal link between diabetes and cataracts. DC datasets were analyzed for differential gene expression, WGCNA, and protein-protein interactions to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39639475
DOI: 10.1080/13510002.2024.2420563
PMCID: PMC11626871

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