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Article

Extrajunctional CLDN10 cooperates with LAT1 and accelerates clear cell renal cell carcinoma progression

5 Dec 2024

Abstract excerpt

BACKGROUND & AIMS: In addition to their adhesive properties, cell adhesion molecules such as claudins (CLDNs) exhibit signaling ability to organize diverse cellular events. Although the CLDN-adhesion signaling stimulates or inhibits cancer progression, the underlying mechanism remains poorly established. Here, we verified whether and how CLDN10 promotes intracellular signals and malignant phenotypes in clear cell...

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PMID: 39639312
DOI: 10.1186/s12964-024-01964-5

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