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Article

A single mutation in bovine influenza H5N1 hemagglutinin switches specificity to human receptors.

Science (New York, N.Y.) - 6 Dec 2024

Lin Ting-Hui, Zhu Xueyong, Wang Shengyang, Zhang Ding, McBride Ryan, Yu Wenli, Babarinde Simeon, Paulson James C, Wilson Ian A

Abstract excerpt

In 2024, several human infections with highly pathogenic clade 2.3.4.4b bovine influenza H5N1 viruses in the United States raised concerns about their capability for bovine-to-human or even human-to-human transmission. In this study, analysis of the hemagglutinin (HA) from the first-reported human-infecting bovine H5N1 virus (A/Texas/37/2024, Texas) revealed avian-type receptor binding preference. Notably, a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39636969
DOI: 10.1126/science.adt0180

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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