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Article

Epidermal Growth Factor Receptor (EGFR) and SMAD4 negatively correlated in the progression of gallbladder cancer in Eastern Indian patients.

BMC gastroenterology - 3 Dec 2024

Choudhury Sounetra, Ghosh Sandip, Chakraborty Prosenjeet, Pal Sayari, Ghosh Koustuv, Saha Subhankar, Midha Jitesh, Sankar Vinu, Mohata Abhisek, Chattopadhyay Bitan Kumar, Ghosh Shibajyoti, Das Soumen, Basu Biswarup, Sikdar Nilabja

Abstract excerpt

BACKGROUND AND INTRODUCTION: Two and half percent of the Indian population suffer from gallbladder cancer (GBC). The primary factors that lead GBC are associated with mutation of several protooncogenes such as EGFR, ERBB2, Myc, and CCND1 along with dysregulation of several tumor suppressor genes such as SMAD4 and CDKN2A. Bacterial infection caused by S.typhi and H.pylori are also hypothesized to be potential...

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PMID: 39623311
DOI: 10.1186/s12876-024-03485-4
PMCID: PMC11613908

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