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Article

Adaptations of Trypanosoma brucei to gradual loss of kinetoplast DNA: Trypanosoma equiperdum and Trypanosoma evansi are petite mutants of T. brucei.

Proceedings of the National Academy of Sciences of the United States of America - 12 Feb 2008

Lai De-Hua, Hashimi Hassan, Lun Zhao-Rong, Ayala Francisco J, Lukes Julius

Abstract excerpt

Trypanosoma brucei is a kinetoplastid flagellate, the agent of human sleeping sickness and ruminant nagana in Africa. Kinetoplastid flagellates contain their eponym kinetoplast DNA (kDNA), consisting of two types of interlocked circular DNA molecules: scores of maxicircles and thousands of minicircles. Maxicircles have typical mitochondrial genes, most of which are translatable only after RNA editing. Minicircles...

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Share to Adaptation, Physiological
Share to DNA, Kinetoplast

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Protozoan

Share to Microscopy, Electron

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Share to Sequence Homology, Amino Acid

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Identifiers

PMID: 18245376
DOI: 10.1073/pnas.0711799105
PMCID: PMC2538871

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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