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Sputum metagenomics reveals a multidrug resistant Pseudomonas-dominant severe asthma phenotype in an Asian population.

Respirology (Carlton, Vic.) - 1 Mar 2025

Ivan Fransiskus Xaverius, Tiew Pei Yee, Jaggi Tavleen Kaur, Thng Kai Xian, Pang Pee Hwee, Ong Thun How, Abisheganaden John Arputhan, Koh Mariko Siyue, Chotirmall Sanjay H

Abstract excerpt

BACKGROUND AND OBJECTIVE: While the lung microbiome in severe asthma has been studied, work has employed targeted amplicon-based sequencing approaches without functional assessment with none focused on multi-ethnic Asian populations. Here we investigate the clinical relevance of microbial phenotypes of severe asthma in Asians using metagenomics. METHODS: Prospective assessment of clinical, radiological, and...

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PMID: 39622769
DOI: 10.1111/resp.14863

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C2

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