Article
A severe asthma phenotype of excessive airway Haemophilus influenzae relative abundance associated with sputum neutrophilia.
Clinical and translational medicine - 1 Sept 2024
Versi Ali, Azim Adnan, Ivan Fransiskus Xaverius, Abdel-Aziz Mahmoud I, Bates Stewart, Riley John, Uddin Mohib, Zounemat Kermani Nazanin, Maitland-Van Der Zee Anke-H, Dahlen Sven-Eric, Djukanovic Ratko, Chotirmall Sanjay H, Howarth Peter, Adcock Ian M, Chung Kian Fan
Abstract excerpt
BACKGROUND: Severe asthma (SA) encompasses several clinical phenotypes with a heterogeneous airway microbiome. We determined the phenotypes associated with a low α-diversity microbiome. METHODS: Metagenomic sequencing was performed on sputum samples from SA participants. A threshold of 2 standard deviations below the mean of α-diversity of mild-moderate asthma and healthy control subjects was used to define those...
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