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Article

INCA033989: the first shot on goal for MPNs?

Blood - 28 Nov 2024

Benlabiod Camelia, Psaila Bethan

Abstract excerpt

ABSTRACT: In this issue of Blood, Reis et al1 identify a monoclonal antibody, INCA033989, that selectively targets mutant calreticulin (mutCALR) in myeloproliferative neoplasms (MPNs), inhibiting its oncogenic activity without affecting normal hematopoiesis.

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Identifiers

PMID: 39607716
DOI: 10.1182/blood.2024026811

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Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

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INCA033989: the first shot on goal for MPNs?PMID 39607716Read ↗

Selective targeting of mutated calreticulin by the monoclonal antibody INCA033989 inhibits oncogenic function of MPN.Semantic proximity Read ↗

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