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A Murine Bispecific Antibody Efficiently Redirects T Cells Against Calr Mutated Stem Cells In Vivo.

American journal of hematology - 1 Apr 2026

Xiong Shengen, Wais Tamara, Varga Cecilia, Schueller Christina, Achyutuni Sarada, Kralovics Robert

Abstract excerpt

Calreticulin (CALR) mutations are prevalent in 20%-30% of patients with BCR::ABL1-negative myeloproliferative neoplasms (MPN). Mutant calreticulin (mutCALR), presented by the thrombopoietin receptor (MPL, also known as TPOR or CD110) on the surface of the disease-initiating MPN progenitors, represents an ideal target for curative immunotherapies including monoclonal antibodies, bispecific T cell engaging...

Topics

Animals
Mice
Antibodies, Bispecific
Calreticulin
Mutation
Humans
Mice, Transgenic
T-Lymphocytes
Myeloproliferative Disorders

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Open in PubMed Open full text

Identifiers

PMID: 41532194
DOI: 10.1002/ajh.70206
PMCID: PMC12994124

Genes

ABL1
BCR
CALR
CD4
F3
MPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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A Murine Bispecific Antibody Efficiently Redirects T Cells Against Calr Mutated Stem Cells In Vivo.PMID 41532194Read ↗

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