[Mutant gene expression in murine aggregation chimeras. 5. The ocular retardation and fidget genes].

Abstract excerpt

Analysis of ocular retardation (or) and fidget (fi) genes expression in 18 day old embryos, 10 and 20 day old or/or C/C----+/+ c/c and fi/fi or/or C/C----+/+ +/+ c/c mice has shown that genes or and fi are active in developing retina and suppress cell proliferation. Structural defects of retina and decrease in the eye size in the chimaeras, compared to the normal embryos, were observed already in the presence of...

Topics

• Animals
• Chimera
• Gene Expression Regulation
• Genes, Recessive
• Genotype
• Gestational Age
• Homozygote
• Mice
• Microphthalmos
• Mutation
• Retina