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[The interaction of the coloboma and aphakia mutant genes in mice].

Izvestiia Akademii nauk SSSR. Seriia biologicheskaia - 1 Jan 2000

Koniukhov B V, Sazhina M V

Abstract excerpt

The eye development has been studied in the 12-day-old, 14-day-old embryos and in neonates of Cm/+ ak/ak genotype. The gene coloboma (Cm) in heterozygous state causes a typical coloboma of the iris and the gene aphakia (ak) blocks the lens development in the homozygotes. It has been shown that in Cm/+ ak/ak mice the eyes go through mainly the same abnormal development as that in +/+ ak/ak animals. In mice of both...

Topics

Animals
Aphakia
Coloboma
Eye
Female
Gene Expression Regulation
Genes, Dominant
Genes, Recessive
Genotype
Iris
Male
Mice
Mice, Inbred C57BL

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Mutation

Source

Identifiers

PMID: 2621277

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2621277-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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