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[The interaction of the coloboma and aphakia mutant genes in mice].

Izvestiia Akademii nauk SSSR. Seriia biologicheskaia - 1 Jan 2000

Koniukhov B V, Sazhina M V

Abstract excerpt

The eye development has been studied in the 12-day-old, 14-day-old embryos and in neonates of Cm/+ ak/ak genotype. The gene coloboma (Cm) in heterozygous state causes a typical coloboma of the iris and the gene aphakia (ak) blocks the lens development in the homozygotes. It has been shown that in Cm/+ ak/ak mice the eyes go through mainly the same abnormal development as that in +/+ ak/ak animals. In mice of both...

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PMID: 2621277

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