Virulence-associated variants in Cryptococcus neoformans sequence type 93 are less likely to be associated with population structure compared to independent rare mutations.

Abstract excerpt

Cryptococcus neoformans is a pathogenic yeast that is the causative agent of cryptococcal meningitis. While it is well known that the genotype of C. neoformans impacts patient outcomes, the reason for this association has not been well elucidated. In this study, we examined the relationship between two subpopulations in the sequence type 93 clade of C. neoformans: ST93A and ST93B. We found extensive linkage...

Topics

• Cryptococcus neoformans
• Polymorphism, Single Nucleotide
• Virulence
• Linkage Disequilibrium
• Humans
• Mutation
• Genotype
• Cryptococcosis
• Phylogeny
• Virulence Factors