Article
MIR27A rs895819 CC Genotype Severely Reduces miR-27a Plasma Expression Levels.
Genes - 20 Nov 2024
Ragia Georgia, Pallikarou Myria, Michou Chrysoula, Manolopoulos Vangelis G
Abstract excerpt
Background/Objectives:MIR27A rs895819 polymorphism has emerged as a potential additional pharmacogenomic marker of fluoropyrimidine response. Current evidence on its potential effect on miR-27a expression, which represses DPD activity, leading to DPD deficiency and increased fluoropyrimidine-associated toxicity risk, is scarce and inconsistent. We have analyzed the effect of MIR27A rs895819 polymorphism on...
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