MIR27A Gene Polymorphism Modifies the Effect of Common DPYD Gene Variants on Severe Toxicity in Patients with Gastrointestinal Tumors Treated with Fluoropyrimidine-Based Anticancer Therapy.

doi:10.3390/ijms25158503

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Article

MIR27A Gene Polymorphism Modifies the Effect of Common DPYD Gene Variants on Severe Toxicity in Patients with Gastrointestinal Tumors Treated with Fluoropyrimidine-Based Anticancer Therapy.

International journal of molecular sciences - 4 Aug 2024

Ikonnikova Anna, Fedorinov Denis, Gryadunov Dmitry, Heydarov Rustam, Lyadova Marina, Moskalenko Alexey, Mikhailovich Vladimir, Emelyanova Marina, Lyadov Vladimir

Abstract excerpt

To reduce severe fluoropyrimidine-related toxicity, pharmacogenetic guidelines recommend a dose reduction for carriers of four high-risk variants in the DPYD gene (*2A, *13, c.2846A>T, HapB3). The polymorphism in the MIR27A gene has been shown to enhance the predictive value of these variants. Our study aimed to explore whether rs895819 in the MIR27A gene modifies the effect of five common DPYD variants:...

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PMID: 39126072
DOI: 10.3390/ijms25158503
PMCID: PMC11313059

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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