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Article

MIR27A rs895819 TC genotype increases risk of fluoropyrimidine-induced severe toxicity independently of DPYD variations.

Pharmacogenomics - 1 Jan 2024

Ragia Georgia, Biziota Eirini, Koukaki Triantafyllia, Amarantidis Kyriakos, Manolopoulos Vangelis G

Abstract excerpt

Aim: MicroRNA 27a (miR-27a) regulates post-transcriptionally DPD activity. We have analyzed the association of MIR27A rs895819T>C variation, that modulates miR-27a expression, with fluropyrimidine-induced toxicity. Materials & methods: MIR27A rs895819T>C genotyping was conducted by TaqMan® allelic discrimination assay in 313 FP-treated cancer patients. Results: In overdominance (TC vs TT + CC), TC genotype was...

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PMID: 38353109
DOI: 10.2217/pgs-2023-0223

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DPYD

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